Teamwork: The tumor cell edition

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Teamwork: The tumor cell edition by Allison S. Cleary Science Volume 350(6265):1174-1175 December 4, 2015 Copyright © 2015, American Association for the Advancement of Science

Wnt1 tumors with a biclonal organization require both subclones for tumor propagation. Wnt1 tumors with a biclonal organization require both subclones for tumor propagation. Tumors identified as containing genetically distinct luminal Wnt1highHRaswild-type and basal Wnt1lowHRasmutant subclones were separated by fluorescence-activated cell sorting (FACS) into their component cell populations and then transplanted, either separately or as a 1:1 admixture, into mammary fat pads of wild-type host animals. Animals receiving either subclone alone failed to develop tumors, whereas the cell mixture containing both subclones was highly tumorigenic. Allison S. Cleary Science 2015;350:1174-1175 Copyright © 2015, American Association for the Advancement of Science

Allison S. Cleary Science 2015;350:1174-1175 Copyright © 2015, American Association for the Advancement of Science