Fig. 6 The combined therapeutic efficacy of N-pepABS and low dose of Dox on MDA-MB-231 xenografts. The combined therapeutic efficacy of N-pepABS and low.

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Fig. 6 The combined therapeutic efficacy of N-pepABS and low dose of Dox on MDA-MB-231 xenografts. The combined therapeutic efficacy of N-pepABS and low dose of Dox on MDA-MB-231 xenografts. (A to D)Tumor growth was apparently inhibited after the combination use of N-pepABS and Dox. Their volumes and weights were compared and statistically analyzed with different treatment exposures. The bar graph was represented as means ± SD, while *P < 0.05 was thought as significant difference (n = 6), performing nonparametric tests. (E) Necrotic regions were observed by hematoxylin and eosin staining experiments with different treatment exposures. (F) Western blots assays of the expression of CA IX in tumor tissues. Immunofluorescence images of (G) Ki67 illuminated cell proliferation attenuation, and (H) CD31 indicated blood vessel variation with different treatment exposures. Jiayang Li et al. Sci Adv 2019;5:eaax0937 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).