An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment Eli O. Meltzer, MD, Robert B. Berkowitz,

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An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment Eli O. Meltzer, MD, Robert B. Berkowitz,

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Presentation transcript:

An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment Eli O. Meltzer, MD, Robert B. Berkowitz, MD, Elliott B. Grossbard, MD Journal of Allergy and Clinical Immunology Volume 115, Issue 4, Pages 791-796 (April 2005) DOI: 10.1016/j.jaci.2005.01.040 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Allergen cross-binding to IgE bound to Fcε receptor on mast cell initiates lyn phosphorylation of receptor and Syk activation with downstream effects that include degranulation as well as lipid mediator and cytokine synthesis and release. Journal of Allergy and Clinical Immunology 2005 115, 791-796DOI: (10.1016/j.jaci.2005.01.040) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Park study schedule of events. bid, Two times daily; ECG, electrocardiogram; SGA, subject global assessment; SGTR, subject global therapeutic response. Journal of Allergy and Clinical Immunology 2005 115, 791-796DOI: (10.1016/j.jaci.2005.01.040) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Comparison of improvement (%) in individual symptoms and overall GSC between patients receiving R112 and those receiving placebo. Journal of Allergy and Clinical Immunology 2005 115, 791-796DOI: (10.1016/j.jaci.2005.01.040) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 GSC score over time; park day 1 and 2. Journal of Allergy and Clinical Immunology 2005 115, 791-796DOI: (10.1016/j.jaci.2005.01.040) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions