Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis Caroline Roduit, MD, MPH, Johanna.

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Presentation transcript:

Prenatal animal contact and gene expression of innate immunity receptors at birth are associated with atopic dermatitis Caroline Roduit, MD, MPH, Johanna Wohlgensinger, PhD, Remo Frei, PhD, Sondhja Bitter, MD, Christian Bieli, MD, PhD, Susanne Loeliger, Gisela Büchele, MPH, Josef Riedler, MD, Jean-Charles Dalphin, MD, PhD, Sami Remes, MD, Marjut Roponen, PhD, Juha Pekkanen, MD, Michael Kabesch, MD, Bianca Schaub, MD, Erika von Mutius, MD, MSc, Charlotte Braun-Fahrländer, MD, Roger Lauener, MD Journal of Allergy and Clinical Immunology Volume 127, Issue 1, Pages 179-185.e1 (January 2011) DOI: 10.1016/j.jaci.2010.10.010 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Cumulative prevalence of atopic dermatitis between farmers and nonfarmers (A) and between mothers working and not working on a farm during pregnancy (B). P value based on the χ2 test. Dr, Doctor. Journal of Allergy and Clinical Immunology 2011 127, 179-185.e1DOI: (10.1016/j.jaci.2010.10.010) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Association between prenatal farm animal exposures and atopic dermatitis. OR, 0.80 (95% CI, 0.65-0.99) for atopic dermatitis with each additional farm animal species, P = .04, adjusted for center, atopic mother, sex, smoking during pregnancy, and arming status (GEE analysis). Test of interaction between center and prenatal exposure to farm animal was nonsignificant; P = .81. Journal of Allergy and Clinical Immunology 2011 127, 179-185.e1DOI: (10.1016/j.jaci.2010.10.010) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 The effect of prenatal contact with farm animals and cat on atopic dermatitis by genotypes of TLR2_min16934. Reference group: no prenatal contact with animals. OR adjusted for study center, mother with atopy, sex, smoking during pregnancy, and farming status. P = .09 for interaction term between TLR2_min16934 and prenatal farm animal contact. P = .02 for interaction term between TLR2_min16934 and prenatal cat contact. Journal of Allergy and Clinical Immunology 2011 127, 179-185.e1DOI: (10.1016/j.jaci.2010.10.010) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Association between the development of atopic dermatitis in the first 2 years of life and the gene expression of TLRs and CD14 at birth. GMR, Ratio of the TLRs geometric mean in children with atopic dermatitis compared with children without atopic dermatitis. ∗Adjusted for farmer, mother with atopy, sex, older siblings, smoking during pregnancy, and study center. Journal of Allergy and Clinical Immunology 2011 127, 179-185.e1DOI: (10.1016/j.jaci.2010.10.010) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Cumulative incidence of atopic dermatitis, stratified between tertiles of gene expression of TLR5 (A) and TLR9 (B) at birth. A, TLR5. The cumulative incidences of atopic dermatitis by age 2 years were significantly different between the tertiles of TLR5: P = .003. B, TLR9. The cumulative incidences of atopic dermatitis by age 2 years were significantly different between the tertiles of TLR9: P < .001. cb, Cord blood. Journal of Allergy and Clinical Immunology 2011 127, 179-185.e1DOI: (10.1016/j.jaci.2010.10.010) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions