Molecular Therapy - Nucleic Acids

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Molecular Therapy - Nucleic Acids An Analysis of the Expression and Association with Immune Cell Infiltration of the cGAS/STING Pathway in Pan-Cancer  Xiang An, Yuanyuan Zhu, Tongsen Zheng, Guangyu Wang, Minghui Zhang, Jiade Li, Hongbo Ji, Shijun Li, Shucai Yang, Dandan Xu, Zhiwei Li, Tianzhen Wang, Yan He, Lei Zhang, Weiwei Yang, Ran Zhao, Dapeng Hao, Xiaobo Li  Molecular Therapy - Nucleic Acids  Volume 14, Pages 80-89 (March 2019) DOI: 10.1016/j.omtn.2018.11.003 Copyright © 2018 The Author(s) Terms and Conditions

Molecular Therapy - Nucleic Acids 2019 14, 80-89DOI: (10. 1016/j. omtn Copyright © 2018 The Author(s) Terms and Conditions

Figure 1 The Expression of the cGAS/STING Pathway in Different Types of Cancer TCGA RNA-seq data were first TPM normalized, and the differential expression was assessed by an unpaired t test to generate a p value. (A) The expression of MB21D1 in pan-cancer. (B) The expression of TMEM173 in pan-cancer. (C) The expression of TBK1 in pan-cancer. (D) The expression of IRF3 in pan-cancer. *p < 0.05; **p < 0.01; ***p < 0.001. Molecular Therapy - Nucleic Acids 2019 14, 80-89DOI: (10.1016/j.omtn.2018.11.003) Copyright © 2018 The Author(s) Terms and Conditions

Figure 2 Promoter Methylation Level of the cGAS/STING Pathway in Different Types of Cancer The p value was assessed by an unpaired t test. (A) Methylation level of MB21D1 gene promoter. (B) Methylation level of TMEM173 gene promoter. (C) Methylation level of TBK1 gene promoter. (D) Methylation level of IRF3 gene promoter. *p < 0.05; **p < 0.01; ***p < 0.001. Molecular Therapy - Nucleic Acids 2019 14, 80-89DOI: (10.1016/j.omtn.2018.11.003) Copyright © 2018 The Author(s) Terms and Conditions

Figure 3 Somatic Mutation Rate of the MB21D1, TMEM173, TBK1, and IRF3 Genes in Various Tumors Molecular Therapy - Nucleic Acids 2019 14, 80-89DOI: (10.1016/j.omtn.2018.11.003) Copyright © 2018 The Author(s) Terms and Conditions

Figure 4 The Correlation between the Expression of cGAS/STING Signaling and the Infiltration of Immune Cells (A) The correlation between the expression of MB21D1, TMEM173, TBK1, IRF3, and the infiltration of activated CD4, CD8 T cell, and DC. Node color is determined by correlation, and node size indicates the significance of correlation. (B) The high expression of TMEM173 predicts a favorable prognosis of metastatic melanoma patients treated with monoclonal antibody against CTLA-4. (C) The high expression of TBK1 indicates a favorable prognosis of metastatic melanoma patients treated with monoclonal antibody against CTLA-4. Molecular Therapy - Nucleic Acids 2019 14, 80-89DOI: (10.1016/j.omtn.2018.11.003) Copyright © 2018 The Author(s) Terms and Conditions

Figure 5 cGAS/STING Pathway Expression as a Prognostic Factor in Various Tumors (A) MB21D1. (B) TBK1. (C) IRF3. Molecular Therapy - Nucleic Acids 2019 14, 80-89DOI: (10.1016/j.omtn.2018.11.003) Copyright © 2018 The Author(s) Terms and Conditions

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