CpG oligodeoxynucleotide (CpG ODN)–induced activation of different types of primary malignant B cells. CpG oligodeoxynucleotide (CpG ODN)–induced activation.

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CpG oligodeoxynucleotide (CpG ODN)–induced activation of different types of primary malignant B cells. CpG oligodeoxynucleotide (CpG ODN)–induced activation of different types of primary malignant B cells. Primary malignant B cells were incubated with medium alone (open columns) or with CpG ODN 2006 (closed columns), or the control ODN (grey columns). After 48 hours, the expression of CD40, CD54, CD80, CD86, MHC I, MHC II, and CD64 was measured by flow cytometry. Columns, means (n = no. samples) of the median fluorescence intensity of different surface molecules relative to the baseline expression on day 0 (set as 1); bars, ±SE. *, P < 0.05; **, P < 0.005. Bernd Jahrsdorfer et al. Clin Cancer Res 2005;11:1490-1499 ©2005 by American Association for Cancer Research