Fig. 1 Undetectable ALK expression in monocytes and macrophages.

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Fig. 1 Undetectable ALK expression in monocytes and macrophages. Undetectable ALK expression in monocytes and macrophages. (A) ALK mRNA expression in tissues according to the GTEx project. TPM, transcripts per million. (B) ALK expression in murine cell lines [top: SP8 anti-ALK antibody (1:1000); bottom: F-12 anti-ALK antibody (1:100)]. 293T cells transfected with mouse Alk (293T_ALK) and EML4-ALK–expressing TeCla1 cells (positive controls). Untransfected 293T and KP1233 murine KRASG12D-driven NSCLC cells (negative controls). Arrows indicate the full-length (f.l.) ALK or the EML4-ALK fusion. (C) ALK expression in human cell lines [top: D5F3 anti-ALK antibody (1:1000); bottom: F-12 anti-ALK antibody (1:100)]. Human neuroblastoma cell lines SK-N-BE and SH-SY5Y (positive controls). Human B-lymphoma Raji and Ramos cell lines (negative controls). Arrows indicate the full-length ALK or the cleaved ALK. Asterisk indicates the nonspecific band detected by the F-12 antibody. (D) ALK expression in human cell lines [left: D5F3 anti-ALK (1:1000); right: F-12 anti-ALK antibody (1:100)]. THP-1 cells transduced with human ALK receptor (THP-1_ALK) (positive control). THP-1 cells transduced with empty retroviral vector (THP-1_vector) (negative control). H3122 and H2228 NSCLC cell lines carry the EML4-ALK (ex13-ex20) and the EML4-ALK (ex6-ex20) rearrangements that generate fusion proteins of 130 and 90 kDa, respectively. Karpas-299 is an NPM-ALK–rearranged cell line that generates a fusion protein of 80 kDa. Arrows indicate the full-length ALK or the cleaved ALK. Asterisk indicates the nonspecific band detected by the F-12 antibody. Top panels: Short exposure. Bottom panels: Long exposure. (E) Immunohistochemistry performed on an ALK-rearranged NSCLC case (D5F3 anti-ALK antibody) and on an ALCL case (4C5B8 anti-ALK antibody). Tumor cells shown by black arrows; macrophages shown by red arrows. Scale bar, 50 μm. Rafael B. Blasco et al., Sci Transl Med 2018;10:eaar4321 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works