Methylation targets of TET1 in vitro.

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Methylation targets of TET1 in vitro. Methylation targets of TET1 in vitro. A, Principal component analysis of DREAM methylation data for MDA-MB-231 parental cell line, empty vector pooled cells, empty vector single clone cells, and TET1 KO-1, KO-2, KO-3 single clone cells (all in triplicate except for parental cells). B, Active TET1 demethylation sites in MDA-MB-231 cells (top) and TET1 protected sites (bottom). Includes average methylation values for NBE, empty vector control and TET1 KO cells. y-axis, average DNA methylation (%). C, Pathway analysis of genes with hypermethylated promoters in TET1 KO clones that are at active TET1 demethylation sites (top) and TET1 protected sites (bottom). x-axis, −log10(P). D, Active TET1 demethylation sites in Hs578T cells (top) and TET1 protected sites (bottom). Charly Ryan Good et al. Cancer Res 2018;78:4126-4137 ©2018 by American Association for Cancer Research