P53 restoration in a syngeneic transplant model of Mdm2Tg p53Neo/Neo CreER angiosarcoma. p53 restoration in a syngeneic transplant model of Mdm2Tg p53Neo/Neo.

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p53 restoration in a syngeneic transplant model of Mdm2Tg p53Neo/Neo CreER angiosarcoma. p53 restoration in a syngeneic transplant model of Mdm2Tg p53Neo/Neo CreER angiosarcoma. A, growth curves of transplanted Mdm2Tg p53Neo/Neo CreER angiosarcomas treated with tamoxifen (n = 8) and vehicle control (n = 3). B, comparison of tumor volume doubling time calculated from tumor growth curves between tamoxifen-treated and vehicle control groups. Tumor volume doubling time was calculated based on the exponential curve fit of tumor volume against time. C, Western blot analysis of p53 and p21 levels in transplanted Mdm2Tg p53Neo/Neo CreER angiosarcomas treated with tamoxifen and vehicle control. Three representative tumors from both control and tamoxifen-treated groups were examined. Protein lysate from an Mdm2−/−p53−/− spleen served as negative control. D, qRT-PCR analysis of expression of p53 target genes p21 and Puma in transplanted Mdm2Tg p53Neo/Neo CreER angiosarcomas treated with tamoxifen and vehicle control. Data were normalized to expression in a vehicle-treated control. Qin Li et al. Mol Cancer Res 2014;12:901-911 ©2014 by American Association for Cancer Research