Ibrutinib decreases ofatumumab-mediated complement-dependent cytotoxicity. Ibrutinib decreases ofatumumab-mediated complement-dependent cytotoxicity. A,

Slides:

Advertisements

Similar presentations

C1q g/L C2 g/L C3 g/L C4 g/L A. B. C.D. E. Supplementary Figure 1 - Middleton et al. NR Supplementary Figure 1. Complement concentrations in CLL patient.

Advertisements

The expression and signaling of FGFR3 in WM cells.

Melanoma donor (MD) NK cells are functionally impaired/exhausted.

Galectin-9 binding to Tim-3 renders activated human CD4+ T cells less susceptible to HIV-1 infection by Shokrollah Elahi, Toshiro Niki, Mitsuomi Hirashima,

FLT3 ligand administration after hematopoietic cell transplantation increases circulating dendritic cell precursors that can be activated by CpG oligodeoxynucleotides.

A, RT-qPCR of ROR1 mRNA expression in B-CLL cells and a panel of human and rhesus macaque tissues. A, RT-qPCR of ROR1 mRNA expression in B-CLL cells and.

B7-H4 expression correlates with MHC-I expression and improved prognosis in patients with breast cancer. B7-H4 expression correlates with MHC-I expression.

Fig. 3. Applying the rapid test to analyze human patient sera.

DCs induce the proliferation of autologous T cells.

A and B, ROC curves of the proteomics panel diagnosis.

Fig. 1 Effect of preinfection β7Hi CD45RA−CD4+ T cell frequency on HIV acquisition risk in CAPRISA 004 study. Effect of preinfection β7Hi CD45RA−CD4+ T.

Quantification of MHC-I, β2m, and T-cell subsets.

Figure 3 Flu immunization–induced changes in the proportions and absolute numbers of RORγt-expressing CD4+ and CD8+ T cells Flu immunization–induced changes.

Figure 1 Flu immunization–induced changes in the proportions and absolute numbers of T cells and their relevant subpopulations Flu immunization–induced.

Serial measurements of serum glucose, anion gap, serum carbon dioxide, and serum triglycerides throughout the patient's hospital stay. Serial measurements.

Anifrolumab does not elicit antibody-dependent cell-mediated cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC) activity. Anifrolumab does.

A and B: Flow cytometric analysis of the effect of MRP-8/14 in the serum of a type 1 diabetic patient on the surface expression of CD11b and CD118. A and.

Cytotoxic activity of HER2-lytic hybrid peptide.

Effect of nucleoside analogues on DNA repair response initiated by 4-HC. Effect of nucleoside analogues on DNA repair response initiated by 4-HC. A, CLL.

FAK overexpression in invasive human breast cancer and DCIS

FAK overexpression in invasive human colon cancer and colon dysplasia.

Colony-forming capacity of CD34+ cells with and without CLL-1 expression. Colony-forming capacity of CD34+ cells with and without CLL-1 expression. CD34+

Β-Cryptoxanthin at a concentration of 10 μmol/L decreases proliferation in HCT116 cells after 6 and 8 days of treatment. β-Cryptoxanthin at a concentration.

CLL-1 expression in patients with AML and normal donors.

CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated with a longer survival. CD8, galectin-3, galectin-9, and the M1/M2 ratio are associated.

Pre- and post-vorinostat values of ER-related gene expression using the Oncotype DX 21-gene assay. Pre- and post-vorinostat values of ER-related gene expression.

Correlation of miR-21 expression levels with DEGs in 28 bladder cancer cell lines. Correlation of miR-21 expression levels with DEGs in 28 bladder cancer.

PD-1 inhibition stimulates the proliferation and cytokine secretion of exhausted/senescent CD8+ T cells in vitro. PD-1 inhibition stimulates the proliferation.

Predictive value of the FGFR3 mutation assay increases with multiple consecutive FGFR3-positive urine samples. Predictive value of the FGFR3 mutation assay.

FGFR3 mutation analysis of a selection of urine samples from patients included with an FGFR3-mutant (MT) tumor. FGFR3 mutation analysis of a selection.

A, iDC (top) or mDC (bottom) were loaded with or without 10 pfu/cell reovirus, and cultured with Mel-888 cells in the presence of blocking serum. A, iDC.

Melanoma patient monocytes have altered expression of inflammatory and surface markers. Melanoma patient monocytes have altered expression of inflammatory.

Increase in proliferation and activation of immune cells in peripheral blood after NKTR-214 treatment. Increase in proliferation and activation of immune.

A, change in Ki-67 expression (percent of cells staining positive) over the course of the intervention. A, change in Ki-67 expression (percent of cells.

Alkaline Comet assay showing DNA break formation after 6-TG treatment, implying more SSBs generated in MMR+ cells. Alkaline Comet assay showing DNA break.

ALT-803 stimulates proliferation and activation of human NK cells and T cells in vitro. ALT-803 stimulates proliferation and activation of human NK cells.

Uptake of TEX by DCs in vivo.

Immunologic and pharmacokinetic studies.

Growth curve (a) and doubling time (b) of glioma cells.

Duration of treatment and intervals of radiographic and ctDNA response

PAP- and PA2024-specific CTLs at week 0 (prior to sipuleucel-T infusion) and at weeks 6 and 26 post–sipuleucel-T treatment. PAP- and PA2024-specific CTLs.

SY-1425 induces maturation in RARA-high AML

Gene expression levels of ESR1 (A), ERBB2 (B), MiK67(C), and PCNA (D) in pre- and postneoadjuvant chemotherapy samples (n = 21). Gene expression levels.

PSMA expression in pre- and posttreatment prostate carcinoma serum.

Reduced klotho expression in pancreatic cancer.

Correlations of the breast cancer hypoxia metagene with Ki67 and the proliferation metagene. Correlations of the breast cancer hypoxia metagene with Ki67.

Intratumoral changes in critical lymphocyte populations and numbers after NKTR-214 treatment. Intratumoral changes in critical lymphocyte populations and.

Scatter plot of serum OPN levels and its correlation with patient survival. Scatter plot of serum OPN levels and its correlation with patient survival.

Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex treatment. Tumor-resident CD8+ T cells rapidly expand after IL-15/IL-15Rα complex.

ODC protein expression in paired benign and cancer tissue obtained from patients with PCA. The protein expression was measured by immunoblot analysis in.

CPI-444 enhances T-cell activation in MC38 tumors.

Anti-CD40 activates TAMs and recruits inflammatory monocytes.

Inhibition of CD20 mRNA expression by ibrutinib correlates with reduced NF-κB activity. Inhibition of CD20 mRNA expression by ibrutinib correlates with.

Decreased dopamine uptake following downregulation of SLC6A3.

CpG oligodeoxynucleotide (CpG ODN)–induced activation of different types of primary malignant B cells. CpG oligodeoxynucleotide (CpG ODN)–induced activation.

Reduced expression of the tumor suppressor PTEN occurs in tumors with both squamous cell and adenocarcinoma histology. Reduced expression of the tumor.

Cellular pharmacology of F-ara-A and Cl-F-ara-A.

Flow cytometric gating strategy used to identify CD69 surface expression on CD4 (left paired columns) and CD8 (right paired columns) T lymphocytes. Flow.

Schedule-dependent impact of costimulated activated T-cell transfer on T-cell reconstitution after tandem stem cell transplant. Schedule-dependent impact.

A and B, linearity of the preamplification step shown by a similar expression pattern of ERα mRNA in four breast tumor samples pre– and post–linear amplification.

Measurements of the apoptotic response of CLL cells to radiation and the association with elevated genomic complexity. Measurements of the apoptotic response.

Regression analysis showing the positive correlation between number of months since the prior chemotherapy regimen (X axis) and the difference between.

Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105. Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105.

Correlations between APOBEC expression and immune cell markers across 22 cancer types. Correlations between APOBEC expression and immune cell markers across.

Comparison of MLTC responses to tumor/peptide stimuli at day 18 and day 34 of growth. Comparison of MLTC responses to tumor/peptide stimuli at day 18 and.

Overexpression of SUFU and GLI1 in the poor clinical outcome subgroup was confirmed by real-time PCR along with its association with disease progression.

Systemic inflammation in patients with severe neurotoxicity (NTX).

The inverse correlation between PARP1 and PD-L1, PAR, and p-STAT3 expression in surgical specimens of ovarian cancer. The inverse correlation between PARP1.

Increased blood–CSF barrier permeability during neurotoxicity (NTX).

Inhibition of stromal cell–induced survival of primary B-CLL cells by cyclopamine in vitro. Inhibition of stromal cell–induced survival of primary B-CLL.

Presentation transcript:

Ibrutinib decreases ofatumumab-mediated complement-dependent cytotoxicity. Ibrutinib decreases ofatumumab-mediated complement-dependent cytotoxicity. A, flow cytometric analysis of CDC mediated by ofatumumab in 33% normal human serum (NHS) against CLL cells obtained from 12 patients before treatment (pre), the day after treatment began (day 2), and at 2 and 6 months. B, correlation of ibrutinib effect on CD20 expression (x-axis) and CDC (y-axis) in the patients shown in A, n = 12. C, CLL samples from the 10 patients with >20% decrease in CD20 expression and CDC were reassessed for CD20 expression and susceptibility to CDC after 1 to 4 days of culture in AIM V media. Symbols represent mean values. P values for all comparisons were calculated using the two-tailed Student paired t test. Correlations were determined using the Pearson test. The whiskers on all box plots depict the range (minimum and maximum values). Martin Skarzynski et al. Clin Cancer Res 2016;22:86-95 ©2016 by American Association for Cancer Research