Gdx rats exhibit increased BDNF-ir in the MF pathway.

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Gdx rats exhibit increased BDNF-ir in the MF pathway. Gdx rats exhibit increased BDNF-ir in the MF pathway. A, BDNF-ir in a sham (A1) and Gdx rat (A2) using a rabbit polyclonal antibody to BDNF (provided by Amgen–Regeneron partners). DG, Dentate gyrus. Arrows point to the MF pathway. Scale bar, 500 μm. B, BDNF-ir in a different sham (B1) and Gdx (B2) rat using a different antibody (mouse monoclonal; Sigma-Aldrich). Scale bar, 500 μm. C, Higher magnification of a coronal section from the same animals as in B. There was greater BDNF-ir in the MFs (arrows) of the Gdx rat. MOL, Molecular layer; GCL, granule cell layer; HIL, hilus. Scale bar, 100 μm. D, Area CA3 of the same sections used in C show MF staining (arrows) that is darker in the Gdx rat. Scale bar, 100 μm. E1, A timeline is shown for experiments where rats were subjected to surgery at ∼60 d of age and perfusion-fixed ∼2 weeks later. E2, Mean grayscale values (measured as described in Fig. 9H1). Sections from Gdx rats exhibited greater values than sham rats: *p < 0.05 (Student's t test). F1, The timeline is shown for experiments where rats had surgery at ∼60 d of age and were perfused ∼2 months later. F2, Sections from Gdx rats had greater values than sham rats: *p < 0.05 (Student's t test). Vanessa A. Skucas et al. J. Neurosci. 2013;33:2338-2355 ©2013 by Society for Neuroscience