Cellular pharmacology of F-ara-A and Cl-F-ara-A.

Slides:

Advertisements

Similar presentations

A c i d s & B a s e s. A c i d - B a s e T h e o r i e s A r r h e n i u s B r o n s t e d - L o w r y L e w i s A r r h e n i u s B r o n s t e d - L.

Advertisements

Total ion current-EMS chromatograms of SB939 and its metabolites after incubation in liver microsomal fractions for 60 min at a concentration of 50 μM.

Distribution of informative SNPs with LOH (black bars) on each chromosome (rows, oriented p-arm at the bottom and q-arm at the top of each chromosome)

MMAE resistance and intracellular accumulation.

PKIs block DHT + bombesin-induced transactivation of probasin ARR3 tk-luc and PSA pPUE-E1b-Luc report constructs. PKIs block DHT + bombesin-induced transactivation.

Adipocytes sequester daunorubicin (DNR).

Correlation between MRP1 mRNA expression and CF efflux-blocking factors of MK-571 (A) and between MDR1 mRNA expression and Rh123 efflux-blocking factors.

Leukemic blasts express a “hypoxia signature

Evaluation of top candidate clones for selective killing in bispecific antibody format. Evaluation of top candidate clones for selective killing in bispecific.

Activity of SW480 qHTS runs and podophyllotoxin titration–response profiles of from library and control samples. Activity of SW480 qHTS runs and podophyllotoxin.

Effect of nucleoside analogues on DNA repair response initiated by 4-HC. Effect of nucleoside analogues on DNA repair response initiated by 4-HC. A, CLL.

FAK overexpression in invasive human breast cancer and DCIS

Frequent alterations identified and potential actionability.

A, Overall survival of patients treated with CAR T cells (black line; n = 15). A, Overall survival of patients treated with CAR T cells (black line; n.

Colony-forming capacity of CD34+ cells with and without CLL-1 expression. Colony-forming capacity of CD34+ cells with and without CLL-1 expression. CD34+

Selectivity of SHAL binding to human B-cell lymphoma cell lines.

Effect of anti-CYP3A and anti-CYP2C antibodies on the disappearance of MPA in human liver microsomes (GHL24). Effect of anti-CYP3A and anti-CYP2C antibodies.

CLL-1 expression in patients with AML and normal donors.

Binding and internalization of bispecific immunotoxins.

Effect of nicotinamide and carbogen on 5-FU uptake (measured as SUV3

Pre- and post-vorinostat values of ER-related gene expression using the Oncotype DX 21-gene assay. Pre- and post-vorinostat values of ER-related gene expression.

Correlation between serum visfatin concentrations and the clinical stage (A) and tumor size (B, C) of HCCs. A and B, the correlations were determined by.

VEGF expression in neoplastic and normal prostate tissue.

Predictive value of the FGFR3 mutation assay increases with multiple consecutive FGFR3-positive urine samples. Predictive value of the FGFR3 mutation assay.

FGFR3 mutation analysis of a selection of urine samples from patients included with an FGFR3-mutant (MT) tumor. FGFR3 mutation analysis of a selection.

Peptide dose-response curves were done to estimate the avidity of these HTL for peptide TARP1-14 (A) and TARP14-27 (B-E) using autologous PBMCs and dendritic.

Tamoxifen-treated patients.

Somatic mutational rates and survival analysis of IBD-CRC.

ALDH1A3 expression levels are inversely correlated with the survival of patients with resectable mass-forming and advanced cholangiocarcinoma, respectively.

Effect of SFN on the protein expression of Nrf2, HO-1, and NQO1 in JB6-shMock and JB6-shNrf2 cells. Effect of SFN on the protein expression of Nrf2, HO-1,

Effect of GSK3β inhibition on cell survival and proliferation of glioblastoma cells. Effect of GSK3β inhibition on cell survival and proliferation of glioblastoma.

Location of common clinically relevant mutations in EGFR

Duration of treatment and intervals of radiographic and ctDNA response

PAP- and PA2024-specific CTLs at week 0 (prior to sipuleucel-T infusion) and at weeks 6 and 26 post–sipuleucel-T treatment. PAP- and PA2024-specific CTLs.

Kaplan-Meier survival analysis of p53 mutation in the overall breast tumor series. Kaplan-Meier survival analysis of p53 mutation in the overall breast.

Nested RT-PCR of Mammaglobin and CK19 mRNA in plasma and circulating cells of controls (C) and patients (T) with breast cancer. Nested RT-PCR of Mammaglobin.

Frequency of misrepair studies with increasing concentrations of antibodies against NHEJ repair proteins. Frequency of misrepair studies with increasing.

Gamma camera images at 72 h of patient with T4N2M1 ductal breast cancer (patient 6). Gamma camera images at 72 h of patient with T4N2M1 ductal breast cancer.

Gene expression levels of ESR1 (A), ERBB2 (B), MiK67(C), and PCNA (D) in pre- and postneoadjuvant chemotherapy samples (n = 21). Gene expression levels.

NKT cell recognition of CD1d1 molecules is inhibited by treatment with ascites. NKT cell recognition of CD1d1 molecules is inhibited by treatment with.

WP1066 inhibits the progression of OCIM2 cells through the cell cycle.

PSMA expression in pre- and posttreatment prostate carcinoma serum.

Reduced klotho expression in pancreatic cancer.

Characterization of DNA-PK and PARP-1 levels and activities in the cell lines studied. Characterization of DNA-PK and PARP-1 levels and activities in the.

Representative images demonstrating LOH in breast cancer patients’ paired BM aspirate and primary tumors (T) at D14S62, D14S51, and D8S321, respectively.

A 63-year-old female with lung adenocarcinoma treated with nivolumab, who experienced pseudoprogression. A 63-year-old female with lung adenocarcinoma.

Macroscopic observations of the mogamulizumab-induced skin-related AEs

Mean weight change from original weight of (a) BALB/c (b) DBA/2 mice after one (♦) or two (▴) injections of 10 mg/kg and one (▪) or two (×) injections.

Efficacy summary for patients with gastric/GEJ adenocarcinoma (part B)

A, pretreatment CT scan of pelvic lymphadenopathy (identified by white arrow) in 1 patient with documented response to 1α-OH-D2. A, pretreatment CT scan.

Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Enhanced expression of Cap43 gene by nickel in breast cancer cell lines. Expression.

Mean percentage change from baseline in total IGF-I and the R1507 serum concentration values following a single i.v. administration of R mg/kg (n.

ROC analysis of MIC-1 and CA19-9.

A, Selected 4 quantitative imaging features significantly associated with 3 imaging subtypes, including tumor volume, tumor sphericity, tumor homogeneity.

Western blot analysis for bFGF expression in human glioma cell lines.

Specific reaction with MIB1, M30, and CD31 monoclonal antibodies in primary human cervical carcinoma before (A, C, and E) and after (B, D, and F) Tam treatment.

The best response for target lesions per patient for patients with target lesions assessed at baseline and at least 1 follow-up. The best response for.

AS1411 alters subcellular distribution of PRMT5 in a time-dependent, dose-dependent, and nucleolin-dependent manner. AS1411 alters subcellular distribution.

HPLC chromatograms using mobile phase containing CTAB and OSA showing complete separation of: A, phthaloylglutamine and phthaloylisoglutamine authentic.

Inhibitory effects of nobiletin and luteolin on TPA-induced O2− generation in differentiated HL-60 cells and their cellular uptake. Inhibitory effects.

CpG oligodeoxynucleotide (CpG ODN)–induced activation of different types of primary malignant B cells. CpG oligodeoxynucleotide (CpG ODN)–induced activation.

Validation of NAA's cancer specificity in lung cancer.

Ibrutinib decreases ofatumumab-mediated complement-dependent cytotoxicity. Ibrutinib decreases ofatumumab-mediated complement-dependent cytotoxicity. A,

Schedule-dependent impact of costimulated activated T-cell transfer on T-cell reconstitution after tandem stem cell transplant. Schedule-dependent impact.

Measurements of the apoptotic response of CLL cells to radiation and the association with elevated genomic complexity. Measurements of the apoptotic response.

Biopsies of the vaccination site were obtained 48 h after the first vaccination. Biopsies of the vaccination site were obtained 48 h after the first vaccination.

Regression analysis showing the positive correlation between number of months since the prior chemotherapy regimen (X axis) and the difference between.

Expression of chemokine receptors in A-498 cell line.

Relative frequencies of FGFR aberrations in non–small cell lung carcinoma. Relative frequencies of FGFR aberrations in non–small cell lung carcinoma. A,

Representative images for different populations of detected cells in prostate cancer patients and five rounds of FISH in a CTC. A, Immunofluorescence image.

Presentation transcript:

Cellular pharmacology of F-ara-A and Cl-F-ara-A. Cellular pharmacology of F-ara-A and Cl-F-ara-A. CLL lymphocytes were incubated for 2 h with escalating concentrations (1, 3, 5, 10, 20, 50, and 100 μm) of [8-3H]F-ara-A (A) or [8-3H]Cl-F-ara-A (B). Intracellular triphosphate levels were determined by high-performance liquid chromatography. Each symbol represents samples from one patient. C, CLL lymphocytes from 23 patients were incubated for 2 h with 10 μm [8-3H]F-ara-A or 10 μm [8-3H]Cl-F-ara-A. The relative accumulation of the two analogue triphosphates was compared in each sample. Each point represents samples from one patient. Takahiro Yamauchi et al. Clin Cancer Res 2001;7:3580-3589 ©2001 by American Association for Cancer Research