A, Proportion for different in silico predictions at the RNA level. A, Proportion for different in silico predictions at the RNA level. B, Classification of variants at the RNA level per gene. C, Representation of proportion for different classifications at the protein level. D, Classification of variants at the protein level per gene. E, Final prior-classification using RNA and protein in silico assays for all four MMR genes. F, Final prior-classification using RNA and protein in silico assays per gene. Ester Borras et al. Cancer Prev Res 2017;10:580-587 ©2017 by American Association for Cancer Research