Fig. 3 Characterization of SGN responses to optogenetic stimulation.

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Presentation transcript:

Fig. 3 Characterization of SGN responses to optogenetic stimulation. Characterization of SGN responses to optogenetic stimulation. (A and B) Representative juxtacellular SGN recordings during the first 200 ms of a 900 ms pulse train (1 ms, 20 mW) with a repetition rate of 10 Hz of an exemplary single spike–responding (A) and a multiple spike–responding (B) SGN. (C) Quantification of the first spike jitter elicited per light pulse for single spike–responding (green) and multiple spike–responding (red) SGNs. (D to I) Raster plots and peristimulus time histogram of a single spike–responding (D to F) and a multiple spike–responding (G to I) SGN in response to 900-ms train pulses of 10, 100, and 300 Hz. (J) Vector strength as a function of repetition rate (n = 29). Blue lines correspond to the population mean, green lines to single spike–responding SGNs, red lines to multiple spike–responding SGNs, and dashed black line to acoustic stimulation of control SGN (see fig. S4 for details). (K and L) Distribution (K) and quantification (L) of the cutoff frequency (highest frequency with a significant vector strength) for single spike–responding (green) and multiple spike–responding (red) SGNs. (M) Discharge rate as a function of repetition rate (n = 29). (N) Adaptation ratio as a function of the number of spikes per light pulse in response to 10-Hz light pulse train. A color scale is used to represent the repetition rate. Data are expressed as mean ± SEM, and the statistical difference between groups were tested by Mann-Whitney U test (***P ≤ 0.001). Christian Wrobel et al., Sci Transl Med 2018;10:eaao0540 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works