BEZ235 induces accelerated senescence after radiation (IR) in vitro.

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BEZ235 induces accelerated senescence after radiation (IR) in vitro. BEZ235 induces accelerated senescence after radiation (IR) in vitro. A, representative images of SA-βGal activity after 48 hours treatment (×200 magnification). B, percentage of SA-βGal positive cells. Data are mean ± SEM from 3 independent experiments. ***, P < 0.001; **, P < 0.01; *, P < 0.05. C, Western blot showing total p21 levels after 48 hours treatment in H460 and A549 cells. DMSO, dimethyl sulfoxide. Arun Azad et al. Mol Cancer Res 2011;9:1696-1707 ©2011 by American Association for Cancer Research