Levels of neutrophil infiltration into gliomas correlate with tumor grades and tumor progression. Levels of neutrophil infiltration into gliomas correlate.

Slides:



Advertisements
Similar presentations
Masui_suppl Fig1 TMab-6 sc-7215 (0.5 μg/mL) (1.0 μg/mL) Case: Astro_2
Advertisements

Gr-1+ MDSC in tumor-bearing mice produce IL-6.
A. glioblastoma with high (+++) KIT protein expression.
Scatter plots show the distribution of the complete set of cases at short TE (A) and long TE (B) by using the two first discriminant functions obtained.
Increase in beige/brown adipocyte characteristics in the xenografts from additional breast cancer cell lines. Increase in beige/brown adipocyte characteristics.
Endothelial Ang‐2 upregulation correlates with WHO grading in human gliomas Endothelial Ang‐2 upregulation correlates with WHO grading in human gliomas.
Blockade of EDN3/EDNRB signaling impairs GSC self-renewal, cell migration, and tumorigenic capacity. Blockade of EDN3/EDNRB signaling impairs GSC self-renewal,
NICD1 immunohistochemical staining in normal and tumor tissue.
Group Male Female Total Astrocytoma Grade 2 (%65)13 (%35)7 (%100)20
Bar graph of ADC values (s/mm2) for tumor, contralateral normal tissue, ipsilateral normal tissue, and edema for the group of 15 patients with high-grade.
TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor tissues. TFAP2A is highly expressed in nasopharyngeal carcinoma cells and tumor.
TH-302 has antileukemia activity in an in vivo primary AML xenograft murine model. TH-302 has antileukemia activity in an in vivo primary AML xenograft.
TFAP2A knockdown inhibits tumor growth in vivo.
Geographic colocalization of PD-L1+ tumor cells with infiltrating immune cells in MCC. The predominant pattern of tumor cell PD-L1 expression is at the.
In vivo thrombosis of tumor vasculature.
Matriptase-2 inhibited breast tumor development in vivo.
Rapamycin decreases PD-L1 expression in lung tumors in vivo.
Vascular staining in CWR22R xenograft tumors.
VEGF expression in neoplastic and normal prostate tissue.
Depletion of UCP1 and Myf5 population reduced xenograft growth.
Anti-Flk-1 mAb treatment reduces vessel density in tumors.
Tumors treated with anti-Flk-1 mAb have increased tumor cell apoptosis, reduced tumor cell proliferation, and increased tumor necrosis. s.c. Tumors treated.
Overexpression of DDB2 reduces invasive abilities in lungs of aggressive breast tumor cells. Overexpression of DDB2 reduces invasive abilities in lungs.
Antitumor activity of temozolomide (30 mg/kg for 5 days), talazoparib (0.25 mg/kg twice daily for 5 days), or in combination against xenograft models sensitive.
Induction of cytotoxic activity in humanized SCC3 tumor-bearing mice treated with anti-PD-1 antibody. Induction of cytotoxic activity in humanized SCC3.
ALDH1A3 expression levels are inversely correlated with the survival of patients with resectable mass-forming and advanced cholangiocarcinoma, respectively.
Endothelial cells/microvasucles are increased in prostate cancer versus normal tissues. Endothelial cells/microvasucles are increased in prostate cancer.
ADU-S100–mediated tumor clearance is dependent on CD4+, CD8+ T cells, and NK cells. ADU-S100–mediated tumor clearance is dependent on CD4+, CD8+ T cells,
CD4+ and CD8+ TILs express surface CD137.
N-3 PUFAs promote endometrial cancer cell apoptosis in vitro and in vivo. n-3 PUFAs promote endometrial cancer cell apoptosis in vitro and in vivo. HEC-1-A.
Immunohistochemical analysis of dUTPase in human breast adenocarcinoma
MEDI4736 shows antitumor activity in xenograft mouse models of human cancer. MEDI4736 shows antitumor activity in xenograft mouse models of human cancer.
Immunohistochemical staining of primary and metastatic prostatic carcinomas with anticyclin D1 and anti-Ki67 monoclonal antibodies. Immunohistochemical.
A protracted ketogenic diet increases radiation response in H292 lung cancer xenografts given conventional fractionated radiation. A protracted ketogenic.
Ketogenic diets combined with fractionated radiation treatment results in decreased immunoreactive PCNA in tumor tissue. Ketogenic diets combined with.
The responses of H292 and A549 lung cancer xenografts to hypofractionated radiation were enhanced by the ketogenic diet. The responses of H292 and A549.
Increased levels of acetylated histone H3 are observed in normal PBMCs and circulating tumor cells obtained from patients post-depsipeptide treatment.
In situ analysis of human breast tissue shows the down-regulation of Spry isoforms in breast cancer. In situ analysis of human breast tissue shows the.
Correlations of the breast cancer hypoxia metagene with Ki67 and the proliferation metagene. Correlations of the breast cancer hypoxia metagene with Ki67.
HMQ1611 inhibited breast tumor growth in mice.
Response of Calu-6 tumors to anti-VEGF therapy.
Effect of CDV on human SF7796 xenografts in vivo.
YH25448 less suppresses WT EGFR than osimertinib in vivo.
Mean weight change from original weight of (a) BALB/c (b) DBA/2 mice after one (♦) or two (▴) injections of 10 mg/kg and one (▪) or two (×) injections.
Comparison of in vivo activity of 4D5scFvZZ and 4D5scFv.
PVT1 facilitated gastric cancer progression in a FOXM1-mediated manner
GATA-3 immunostaining was scored semiquantitatively; tumors with
Mean body weights (grams) of athymic female mice implanted with MDA-MB-231 breast carcinoma xenografts. Mean body weights (grams) of athymic female mice.
Progastrin staining in colon adenomas and adenocarcinomas.
Histology (H&E; original magnification, ×100 for B-2P/C-12P/C-64P and ×40 for C-10P; top) of small-sized lung adenocarcinomas and immunohistochemical staining.
Expression of HIF-1α and β-catenin in hypoxic HCC cell lines and HAL-treated xenografts. Expression of HIF-1α and β-catenin in hypoxic HCC cell lines and.
Specific reaction with MIB1, M30, and CD31 monoclonal antibodies in primary human cervical carcinoma before (A, C, and E) and after (B, D, and F) Tam treatment.
A, TSG-6 staining in human prostate.
RhuαVEGF and rhuαVEGF/paclitaxel mediated growth inhibition in an androgen-independent prostate cancer xenograft model. rhuαVEGF and rhuαVEGF/paclitaxel.
Biodistributions 24 hours after injection of different 177Lu-chCE7F(ab′)2 conjugates ( MBq, 13 μg) in tumor-bearing nude mice: effect of the number.
TAE-684 effectively inhibits the growth of H3122 in vivo.
ADC(x 10-3 mm2 /s)±standard diviation
ADC(x 10-3 mm2 /s)±standard diviation
Effect of MZ treatment on lung colony formation in an experimental metastasis. Effect of MZ treatment on lung colony formation in an experimental metastasis.
Reduced expression of the tumor suppressor PTEN occurs in tumors with both squamous cell and adenocarcinoma histology. Reduced expression of the tumor.
Fig. 2. Kaplan-Meier plots for PFS and OS of 37 patients according to histological diagnosis (A and D), the extent of tumor resection (B and E), and adjuvant.
PDL192 and inhibit the growth of xenograft tumors.
Genetic analysis suggests the presence of four clinically relevant groups of histologically defined anaplastic oligodendrogliomas. Genetic analysis suggests.
A, antitumor activity of temozolomide (30 mg/kg for 5 days), talazoparib (0.25 mg/kg twice daily for 5 days), or in combination against “sensitive” Ewing.
BCMab1 confers Fc-FcγR–dependent antitumor activity through both macrophages and NK cells. BCMab1 confers Fc-FcγR–dependent antitumor activity through.
Effect of MIF siRNA on the production of MMP-13 induced by LPA
AXL-on tumors are heterogeneous for AXL expression and EdU incorporation. AXL-on tumors are heterogeneous for AXL expression and EdU incorporation. A,
Immunohistochemical determination of TIM-3 expression in ccRCC.
Antiangiogenic effects of PI3K inhibitor NVP-BKM120.
DHA and dietary n-3 PUFAs inhibit endometrial cancer cell growth in vitro and in xenograft models. DHA and dietary n-3 PUFAs inhibit endometrial cancer.
Presentation transcript:

Levels of neutrophil infiltration into gliomas correlate with tumor grades and tumor progression. Levels of neutrophil infiltration into gliomas correlate with tumor grades and tumor progression. A, neutrophil infiltration into different grade glioma was detected by immunohistochemical staining using an anti-MPO antibody (×200). Grade 4: GB, glioblastoma; GS, gliosarcoma; grade 3: AMOA, anaplastic mixed oligoastrocytoma; AO, anaplastic oligodendroglioma; AA, anaplastic astrocytoma; grade 2: OL, oligodendroglioma; MOA, mixed oligoastrocytoma; LGA, low-grade astrocytoma; NB, normal brain. B, neutrophil infiltration was detected by immunostaining of Ly6B.2 in tumors collected from GICs xenograft nude mice at 2, 3, 4, and 5 weeks (×200). Ji Liang et al. Clin Cancer Res 2014;20:187-198 ©2014 by American Association for Cancer Research