Faecal metabolomics changed after the intervention.

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Presentation transcript:

Faecal metabolomics changed after the intervention. Faecal metabolomics changed after the intervention. (A) OPLS-DA score plots comparing the faecal metabolites before and after the intervention in each group. P values are evaluated by CV-ANOVA. (B) Faecal total short-chain fatty acids concentration before and after the intervention. *p<0.05 and **p<0.01. (C) Heatmap of the median fold changes in faecal metabolite concentrations before and after the intervention. (D) Associations between change in faecal arachidonic acid concentration and changes in plasma proinflammatory marker levels. CV-ANOVA, cross-validation analysis of variance; FDR, false discovery rate; hs-CRP, high sensitivity C-reactive protein; IL, interleukin; LTB4, leukotriene B4; OPLS-DA, orthogonal projection to latent structure-discriminant analysis; PGE2, prostaglandin E2; TNF-α, tumour necrosis factor α; TXB2, thromboxane B2. Yi Wan et al. Gut 2019;68:1417-1429 Copyright © BMJ Publishing Group Ltd & British Society of Gastroenterology. All rights reserved.