Schedule-dependent impact of costimulated activated T-cell transfer on T-cell reconstitution after tandem stem cell transplant. Schedule-dependent impact.

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Schedule-dependent impact of costimulated activated T-cell transfer on T-cell reconstitution after tandem stem cell transplant. Schedule-dependent impact of costimulated activated T-cell transfer on T-cell reconstitution after tandem stem cell transplant. Patients received T cells at 1 of 3 points in this safety and feasibility phase: at days 2, 12, and 90 after stem cell infusion. CD3+, CD3+CD4+ (CD4), CD3+CD8+ (CD8) T cells were enumerated on clinical samples at each time point. X-axis: pretransplant refers to blood drawn immediately before the first transplant; the other time points refer to days after the second transplant. The CD4 and CD8 T-cell count differences between the 3 groups are significant at day 30 (Kruskal—Wallis: P = 0.0021 and 0.0033, respectively). At day 60, CD3, CD4, and CD8 T cells are all significantly different with P = 0.0005, 0.0003, and 0.0007, respectively. Stephan A. Grupp et al. Clin Cancer Res 2012;18:6732-6741 ©2012 by American Association for Cancer Research