Survival RR enhancement according to the specific protocol in treated mice. Survival RR enhancement according to the specific protocol in treated mice. Survival RR significance and 95% CI were estimated by univariate Cox regression analysis for placebo versus all specific treatment protocols. Significance values for male mice: control (Placebo), B3, B6, GR3, A1, A2 A6 (P < 0.001); versus C1, A5 (P < 0.02); versus GR1, D1, D2 (P > 0.05). Significance values for female mice: control versus C2, B1, A1, A3, A4 (P < 0.0001); versus C1, B2, GR1, A2, A7, D1, D3 (P < 0.002); versus B4, B5, GR2, D4 (P > 0.005). Salomón Pérez Cuadrado et al. Clin Cancer Res 2003;9:5776-5785 ©2003 by American Association for Cancer Research