Effects of nutritional supplementation and home visiting on growth and development in young children in Madagascar: a cluster-randomised controlled trial

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Effects of nutritional supplementation and home visiting on growth and development in young children in Madagascar: a cluster-randomised controlled trial Emanuela Galasso, PhD, Ann M Weber, PhD, Christine P Stewart, PhD, Lisy Ratsifandrihamanana, MD, Lia C H Fernald The Lancet Global Health Volume 7, Issue 9, Pages e1257-e1268 (September 2019) DOI: 10.1016/S2214-109X(19)30317-1 Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Duration of exposure and eligibility by cohort, age, and intervention group Figure shows the overlap between age at measurement for the different cohorts at different survey years (2014: baseline, 2015: 1-year follow-up, 2016: study end). Cohorts A (second or third trimester), B (0–5 months of age), and C (6–11 months of age) are the age groups that were used to stratify the sample at baseline. LNS=lipid-based nutrient supplementation. The Lancet Global Health 2019 7, e1257-e1268DOI: (10.1016/S2214-109X(19)30317-1) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Trial profile T0: current standard programme (control group). T1: intensive nutrition counselling. T2: intensive nutrition counselling plus LNS to children aged 6–18 months. T3: intensive nutrition counselling plus LNS to pregnant women, lactating mothers of children aged 0–5 months, and to children aged 6–18 months. T4: intensive nutrition counselling and home visiting for early stimulation of children aged 6–30 months. LNS=lipid-based nutritional supplementation. The Lancet Global Health 2019 7, e1257-e1268DOI: (10.1016/S2214-109X(19)30317-1) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 3 Heterogeneity impact on length-for-age Z score and total ASQ-I score by child median age and intervention group Child age is dichotomised as younger than versus equal to or older than the median values at study end. Total ASQ-I is the age-normalised score for all five subdomains of the ASQ-I. ASQ-I=Ages and Stages Questionnaire: Inventory version. The Lancet Global Health 2019 7, e1257-e1268DOI: (10.1016/S2214-109X(19)30317-1) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions