Changes from baseline in (A) sputum cellularity and (B) endobronchial biopsy cellularity following 1 year of single maintenance and reliever therapy (SMART)

Slides:

Advertisements

Similar presentations

Kaplan-Meier survival curves by frequency of exacerbations in patients with COPD: group A, patients with no acute exacerbations of COPD; group B, patients.

Advertisements

Bland-Altman plot of 129Xe RBC:TP at baseline.

Longitudinal change in FVC, DLCO and RBC:TP.

Cross sectional comparisons of GAPDH and β-actin gene expression.

Elevation of formylated N-terminal peptides in patients with acute respiratory distress syndrome (ARDS). Elevation of formylated N-terminal peptides in.

Effects of nitrate ingestion (10 mg/kg body weight at 0 min) on (A) FENO values, (B) nitrite and (C) nitrate concentrations in oral (filled circles) and.

Comparison of the banding patterns from randomly amplified polymorphic DNA PCR assays of sequential B pseudomallei isolates from each of the cases. Comparison.

Vibration in neonates during high frequency ventilation (HFV, n = 7), conventional mechanical ventilation (CMV, n = 7), and spontaneous breathing (SB,

Comparison of DNA rates between standard lists and BCSP lists across UK. BCSP, Bowel Cancer Screening Programme; DNA, did not attend; NHS, National Health.

Consolidated Standards of Reporting Trials diagram

Vitamin D deficiency is common in α1-antitrypsin deficiency (AATD) and relates to lung function. Vitamin D deficiency is common in α1-antitrypsin deficiency.

Chart 3: Working example of oxygen section for hospital prescription charts (two panels are required on the prescription chart because oxygen may change.

Sedentary time was higher in non-alcoholic fatty liver disease (NAFLD) than healthy controls with fewer sedentary to active transitions (data reported.

A, B, C, D show outcome results for individual symptoms using GSRS-IBS scoring system and mean symptom severity scores before and after IBS dietetic management.

Masashi Maeda et al. Heart Asia 2013;5:7-14

Preprocedure patient ranking of aspects of their care important for obtaining satisfaction with their colonoscopy experience (1=high, 15=low for importance)

Change from baseline in the severity of night-time cough and the frequency of night-time sputum production at week 12 in ACCORD COPD I.17 Data are reported.

Comparison of the delay from referral to endoscopy for subjects with confirmed iron deficiency anaemia, before and after introduction of the Poole iron.

ROC plots of the association of this score, the Rockall Score and the Blatchford Score with RET (a), death (b), and the combined Blatchford outcome (c)

Young people drink significantly less frequently than older people (A), but drink significantly more on each drinking day (panel B). Young people drink.

A, B, C, D show outcome results for individual symptoms using GSRS-IBS scoring system and mean symptom severity scores before and after IBS dietetic management.

Comparison of DNA rates between standard lists and BCSP lists across UK. BCSP, Bowel Cancer Screening Programme; DNA, did not attend; NHS, National Health.

Changes in median exhaled CO levels from baseline to 12 weeks in quitters (n=183) and continuous smokers (n=94). Changes in median exhaled CO levels from.

Area under the receiver operating curve showing 0

Maximum mean (SE) per cent change in serum urate from baseline (Emax) following once-daily oral administration of varying verinurad doses in combination.

Flowchart of patients selected for analysis, illustrating the number of patients at each stage of the study. Flowchart of patients selected for analysis,

Dose–response curve for the rate ratio (solid line) and 95% CIs (dashed lines) of pneumonia as a function of inhaled corticosteroid dose in μg (measured.

Results of comparisons of treatments in the network.

Frequency plots of copy number aberrations (CNAs) are shown for (A) baseline endobronchial lesions of cases (n=12) and (B) baseline endobronchial lesions.

Log faecal calprotectin concentration (mg/l) in the different diagnostic groups. Log faecal calprotectin concentration (mg/l) in the different diagnostic.

Effect of using β-actin as a denominator of IL-2 BAL fluid cell mRNA levels. Effect of using β-actin as a denominator of IL-2 BAL fluid cell mRNA levels.

Comparison of MGM-FCI-MAX-derived with retrained lung cancer prediction models on the training cohort. Comparison of MGM-FCI-MAX-derived with retrained.

Prevalence of LTBI, hepatitis B and hepatitis C, compared with nationally representative samples. Prevalence of LTBI, hepatitis B and hepatitis C, compared.

Countries and areas of the Western Pacific region included within the scope of this study. Taiwan does not have WHO Member State status but is within this.

Pyramid of incidence of acute cough.

Line graph showing mean (SEM) values for ankle pain on activity for intermittent and standard groups at baseline and week 1, 2, 3, 4, and 6 after injury.

Cox regression analysis of the proportion of patients remaining in remission during azathioprine treatment related to minimum observed white blood cell.

Type of circuits used in non-invasive ventilation (NIV) with (A) an expiratory valve and (B) intentional leak, and typical traces obtained with these different.

Cox regression analysis of the proportion of patients remaining in remission during azathioprine treatment related to diagnosis of inflammatory bowel disease.

Kaplan-Meier survival curves by frequency of exacerbations in patients with COPD: group A, patients with no acute exacerbations of COPD; group B, patients.

Mean (95% CI) change in Clinical COPD Questionnaire (CCQ) with pulmonary rehabilitation, according to achievement (+) or non-achievement (−) of the established.

Correlation between age-standardised colorectal cancer incidence (left panel) and mortality rates (right panel) and human development index (HDI) in both.

Time to cessation of rectal bleeding in patients with frank bleeding at baseline. Time to cessation of rectal bleeding in patients with frank bleeding.

The QT interval responses to different pacing rates in a patient in group I. The pacing rate was decreased from 110 to 50 beats/min and the QT interval.

Secondary outcomes: changes from baseline per treatment group (tolerance population). Secondary outcomes: changes from baseline per treatment group (tolerance.

Cumulative incidence of calcification (A) and diabetes (B) since birth in smokers and non-smokers in chronic alcoholic pancreatitis, and cumulative incidence.

Phage activity against Pseudomonas aeruginosa (LESB65 wild type (WT) and adapted strain NP22_2) in an artificial sputum medium (ASM) model. Phage activity.

Forest plot of major bleeding: the measure of the effect of morphine versus nonmorphine on major bleeding in each study was plotted using OR and 95% CI.

Chronic obstructive pulmonary disease (COPD) prevalence (postbronchodilator FEV1/FVC (forced expiratory volume in 1 s/forced vital capacity)

Chest CT scans obtained at the time of first onset of illness (A), at the time of the first visit to our hospital (B), on the day of bronchoscopic examination.

Cox regression analysis of the proportion of patients remaining in remission after stopping azathioprine treatment related to diagnosis of inflammatory.

Bland–Altman plots for (A) interobserver and (B) test-retest reliability, with difference between measurements (y axis) plotted against mean of the measurements.

Phage activity against Pseudomonas aeruginosa (LESB65 wild type and adapted strain NP22_2) infection in the murine lung. Phage activity against Pseudomonas.

Study designs for double-blind single maintenance and reliever therapy (SMART) studies. Study designs for double-blind single maintenance and reliever.

Relationship between the response to bronchodilator and the pre-bronchodilator FEV1 at visit 2. Relationship between the response to bronchodilator and.

Odds ratio (95% confidence intervals) of reporting respiratory symptoms in patients with treated hypothyroidism or inflammatory bowel disease (IBD) compared.

Predicted FEV1/FVC ratio and lower limit of normal in healthy females of different ethnicity GLI. Reproduced with permission from Quanjer PH, Stanojevic.

Changes in responder classification and corresponding subgroup mean FEV1 at each visit after both bronchodilators using (A) American Thoracic Society and.

MADs used in the two study arms.

The highest abnormality of alkaline phosphatase and alanine aminotransferase (ALT) levels in patients undergoing liver biopsy after two years of treatment.

Receiver operating characteristic (ROC) curve analysis for the LENT score and Eastern Cooperative Oncology Group (ECOG) performance score (PS) for the.

(A) Trends in colorectal cancer incidence and mortality in males (M) and females (F) by country (group 1: increasing or stable incidence and mortality).

Comparison of heart failure admissions rates per annum (recorded hospital admissions/ population at risk) in western developed countries 1978 to.

Study design. Study design. Patients who completed the 8-week induction study and achieved clinical response-100 (decrease in Crohn's disease activity.

Receiver operating curve for faecal calprotectin in detecting patients with colorectal neoplasia (carcinoma and adenoma). Receiver operating curve for.

Kaplan-Meier survival curves by severity of exacerbations in patients with COPD: (1) no acute exacerbations of COPD; (2) patients with acute exacerbations.

(A) Percentage of patients achieving remission or response at week 12 or 24 after initiating ova therapy. (A) Percentage of patients achieving remission.

Overview of the screening-detected lung cancers and interval cancers across the four rounds. Overview of the screening-detected lung cancers and interval.

Change in COPD (chronic obstructive pulmonary disease) assessment test (CAT) score after pulmonary rehabilitation corresponding to different responses.

Comparison of total lung capacity (TLC), slow vital capacity (SVC) and carbon monoxide transfer factor (Tlco) in patients with stable interstitial lung.

Presentation transcript:

Changes from baseline in (A) sputum cellularity and (B) endobronchial biopsy cellularity following 1 year of single maintenance and reliever therapy (SMART) (budesonide/formoterol 200/6 twice daily plus as needed) or fixed dose therapy (budesonide/formoterol 800/12 twice daily). Changes from baseline in (A) sputum cellularity and (B) endobronchial biopsy cellularity following 1 year of single maintenance and reliever therapy (SMART) (budesonide/formoterol 200/6 twice daily plus as needed) or fixed dose therapy (budesonide/formoterol 800/12 twice daily). Sputum and biopsy eosinophils decreased significantly with fixed dose combination therapy while with SMART there was a non-significant trend towards increased sputum eosinophils and a significant increase in biopsy eosinophils. p Values are between-treatment comparisons. Kenneth R Chapman et al. Thorax 2010;65:747-752 Copyright © BMJ Publishing Group Ltd & British Thoracic Society. All rights reserved.