Treatment with a Ron inhibitor significantly reduces metastatic outgrowth. Treatment with a Ron inhibitor significantly reduces metastatic outgrowth. A,

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Treatment with a Ron inhibitor significantly reduces metastatic outgrowth. Treatment with a Ron inhibitor significantly reduces metastatic outgrowth. A, quantification of the metastatic tumor burden in the lungs of mice treated prophylactically with vehicle only versus 50 mg/kg BMS-777607/ASLAN002 (n = 6/group). B, quantification of the population of TNF-α–expressing CD11b+ cells in the lungs of tumor-bearing WT and Ron TK−/− hosts treated with vehicle only versus 50 mg/kg BMS-777607/ASLAN002 96 hours after PyMT-MSP tumor cell injection (n = 4 and 3, respectively) and naïve hosts (n = 4). C, quantification of labeled tumor cells 96 hours after intravenous tumor cell injection in animals treated with vehicle or BMS-777607/ASLAN002 following depletion with an anti-CD8 antibody or immunoglobulin G (IgG) control (n = 4, 3, 3, and 4, respectively). D, representative hematoxylin and eosin staining of metastatic growth in the lungs of WT mice treated with vehicle only or 50 mg/kg BMS-777607/ASLAN002 (top pictures represent least metastasis observed in each group and bottom pictures represent most metastasis observed in each group). E, percentage of lung area occupied by metastatic growth in the lungs of mice treated with vehicle only (n = 3) versus 50 mg/kg BMS-777607/ASLAN002 (n = 4). Data are depicted as mean ± SEM. *, P < 0.05; **,P < 0.005 (unpaired, two-sided t test). N.S., not statistically significant. Henok Eyob et al. Cancer Discovery 2013;3:751-760 ©2013 by American Association for Cancer Research