Measurements of the apoptotic response of CLL cells to radiation and the association with elevated genomic complexity. Measurements of the apoptotic response.

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Measurements of the apoptotic response of CLL cells to radiation and the association with elevated genomic complexity. Measurements of the apoptotic response of CLL cells to radiation and the association with elevated genomic complexity. Highly enriched CD19+ cells from 158 CLL patients were irradiated with 5 Gy, and the viable and apoptotic/necrotic cell populations were measured for irradiated and nonirradiated samples using Annexin V-PI fluorescence-activated cell sorting staining ∼40 h postirradiation. Each dot represents the mean normalized fraction of duplicate measurements of cells alive (%alive = % alive irradiated samples/% alive paired nonirradiated samples) for individual CLL samples categorized by hierarchical FISH (all depicted genomic categories other than p53 aberrant or del17p are p53 wild-type). Colored dots, cases with genomic complexity with three or more lesions. Horizontal bars, the mean of values within each genomic category. A, loss complexity. B, total complexity. Peter Ouillette et al. Clin Cancer Res 2010;16:835-847 ©2010 by American Association for Cancer Research