W. chinensis extract induces apoptosis in AR-dependent prostate cancer cells. W. chinensis extract induces apoptosis in AR-dependent prostate cancer cells.

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W. chinensis extract induces apoptosis in AR-dependent prostate cancer cells. W. chinensis extract induces apoptosis in AR-dependent prostate cancer cells. A, prostate cancer cell lines were treated with extract at 10 or 50 μg/mL for 48 h. After staining with FITC-Annexin V/PI, cells were analyzed by flow cytometry. Representative histograms for four set of experiments, quantitatively analyzed by BD FACSDiva software (BD Biosciences). B, effects of W. chinensis extract on the expression of molecular markers for apoptosis and cell cycle in prostate cancer cells. LNCaP and PC-3 cells were grown and treated with vehicle or indicated concentrations of W. chinensis extract for 48 h. Whole-cell extracts were then subjected to Western blotting using antibodies against poly(ADP-ribose) polymerase, caspase-3, caspase-7, Bax, anti–Bcl-xL pRb, Rb, p27, p21, and β-actin (used as loading control). Representative blots of three independent experiments. Chin-Hsien Tsai et al. Clin Cancer Res 2009;15:5435-5444 ©2009 by American Association for Cancer Research