In a Pickle: Is Cornichon Just Relish or Part of the Main Dish?

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In a Pickle: Is Cornichon Just Relish or Part of the Main Dish? Penelope J. Brockie, Andres V. Maricq Neuron Volume 68, Issue 6, Pages 1017-1019 (December 2010) DOI: 10.1016/j.neuron.2010.12.013 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 It Takes Two to Control AMPA Receptor Gating in the Hippocampus Kato et al. (2010a) show that AMPARs coexpressed with the TARP γ-8 in HEK cells exhibit resensitization in the continued presence of glutamate (A) or kainate (B). However, most hippocampal AMPARs are associated with γ-8, yet do not exhibit resensitization. The missing piece appears to be the cornichon CNIH-2. The gating and pharmacology of AMPARs coexpressed with both γ-8 and CNIH-2 in HEK cells are similar to that of native hippocampal receptors and resensitization is abolished (B). Figure adapted from Kato et al. (2010a). Neuron 2010 68, 1017-1019DOI: (10.1016/j.neuron.2010.12.013) Copyright © 2010 Elsevier Inc. Terms and Conditions