Balance of proinflammatory and antiinflammatory cytokines at thoracic cancer operation Darryl M Atwell, MD, Katherine P Grichnik, MD, Mark F Newman, MD,

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Presentation transcript:

Balance of proinflammatory and antiinflammatory cytokines at thoracic cancer operation Darryl M Atwell, MD, Katherine P Grichnik, MD, Mark F Newman, MD, Joseph G Reves, MD, William T McBride, MD The Annals of Thoracic Surgery Volume 66, Issue 4, Pages 1145-1150 (October 1998) DOI: 10.1016/S0003-4975(98)00592-X

Fig 1 Measurements of proinflammatory cytokine tumor necrosis factor-α (TNFα) in thoracotomy patients at six sampling times. The sampling times were: 0 = before induction of anesthesia, 1 = 10 minutes after induction of anesthesia, 2 = 10 minutes after collapse of the nondependent lung, 3 = 10 minutes after reinflation of the nondependent lung, 4 and 5 = 2 and 24 hours after reinflation of the nondependent lung. The Annals of Thoracic Surgery 1998 66, 1145-1150DOI: (10.1016/S0003-4975(98)00592-X)

Fig 2 Measurements of proinflammatory cytokine interleukin-8 (IL-8) in thoracotomy patients at six sampling times. Sampling times as in Figure 1. The Annals of Thoracic Surgery 1998 66, 1145-1150DOI: (10.1016/S0003-4975(98)00592-X)

Fig 3 Measurements of antiinflammatory cytokine interleukin-10 (IL-10) in thoracotomy patients at six sampling times. Sampling times as in Figure 1. The Annals of Thoracic Surgery 1998 66, 1145-1150DOI: (10.1016/S0003-4975(98)00592-X)

Fig 4 Measurements of antiinflammatory cytokine interleukin-1 receptor antagonist (IL-1ra) in thoracotomy patients at six sampling times. Sampling times as in Figure 1. Significant change from baseline sample 0 as assessed by Friedman’s and Wilcoxon signed rank analysis: ∗p < 0.05. The Annals of Thoracic Surgery 1998 66, 1145-1150DOI: (10.1016/S0003-4975(98)00592-X)

Fig 5 Measurements of antiinflammatory cytokine tumor necrosis factor soluble receptor 1 (TNFsr1) in thoracotomy patients at six sampling times. Sampling times as in Figure 1. Significant change from baseline sample 0 as assessed by Friedman’s and Wilcoxon signed rank analysis: ∗p < 0.05. The Annals of Thoracic Surgery 1998 66, 1145-1150DOI: (10.1016/S0003-4975(98)00592-X)

Fig 6 Measurements of antiinflammatory cytokine tumor necrosis factor soluble receptor 2 (TNFsr2) in thoracotomy patients at six sampling times. Sampling times as in Figure 1. Significant change from baseline sample 0 as assessed by Friedman’s and Wilcoxon signed rank analysis: ∗∗p < 0.01. The Annals of Thoracic Surgery 1998 66, 1145-1150DOI: (10.1016/S0003-4975(98)00592-X)