Coronal T2 (A) and sagittal T1 (B), axial T2 (C), and axial ADC (D and E) MR images of a 12-day-old boy. Coronal T2 (A) and sagittal T1 (B), axial T2 (C),

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Coronal T2 (A) and sagittal T1 (B), axial T2 (C), and axial ADC (D and E) MR images of a 12-day-old boy. Coronal T2 (A) and sagittal T1 (B), axial T2 (C), and axial ADC (D and E) MR images of a 12-day-old boy. Global severity score = 43 (fourth quartile) (F). There is diffuse bilateral WM cerebral edema (3 points) and multiple bilateral hemorrhagic WM lesions with restricted diffusion (A–F). There are symmetric bilateral frontal and parietal lesions: severe linear lesions (3 points; C, boxes) and severe cavitary lesions with restricted diffusion (6 points; A, B, and D, ovals), There are bilateral temporal lesions: right (mild punctate, 1 point) and left (moderate punctate, 2 points, not shown). There is restricted diffusion throughout the corpus callosum (3 points, E). No occipital WM lesions are visible. R indicates right; L, left. K.L. Benninger et al. AJNR Am J Neuroradiol 2019;40:347-352 ©2019 by American Society of Neuroradiology