Progesterone receptor (PR)A and PRB isoform receptor domains and post-translational modifications. Progesterone receptor (PR)A and PRB isoform receptor.

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Caption N-terminal domain A/B domain: ligand-independent domain AF1: Activation Function 1 DBD: DNA Binding Domain LBD: Ligand Binding Domain: ligand-dependent.

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Progesterone receptor (PR)A and PRB isoform receptor domains and post-translational modifications. Progesterone receptor (PR)A and PRB isoform receptor domains and post-translational modifications. PRs exist as either A (97 kDa) or B (120 kDa) translated from the same gene by the use of alternate promoters. Each isoform contains a C-terminal ligand-binding domain (LBD), a DNA-binding domain (DBD) and at least two transcriptional activation function (AF) domains. AF1 and AF2 are located within the aminoterminal domain (ATD) and the LBD, respectively. PRB contains an additional AF (AF3) within the unique 164-amino acid B-upstream segment. Adapted from Lange;13 Hill KK, et al.14 Jacques Bonneterre et al. ESMO Open 2016;1:e000072 Copyright © European Society for Medical Oncology. All rights reserved.