LDL cholesterol inhibits Vγ9Vδ2 T-cell activation and cytokine production. LDL cholesterol inhibits Vγ9Vδ2 T-cell activation and cytokine production. Preexpanded.

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LDL cholesterol inhibits Vγ9Vδ2 T-cell activation and cytokine production. LDL cholesterol inhibits Vγ9Vδ2 T-cell activation and cytokine production. Preexpanded γδ (∼80% Vδ2+) T cells were cultured in the absence (Vδ2) or presence of LDL cholesterol (Vδ2 + LDL) for 72 hours. A–B, Percentage of CD69+ Vγ9Vδ2 T cells (A) and MFI for CD69 expression (B), in the absence or presence of LDL and, when indicated, anti–LDL-R or Nystatin. C, RT-qPCR analysis of the mRNA expression of CD69, normalized to the housekeeping gene β2-microglobulin. D, MFI for CD3 surface expression. E, MFI for intracellular IFNγ expression. F–G, RT-qPCR analysis of the mRNA expression of IFNγ (F) and STAT-1 (G) normalized to the housekeeping gene β2-microglobulin. Data are from 3 independent experiments and are presented as mean ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001, 2-tailed Student t test. Neidy V. Rodrigues et al. Cancer Immunol Res 2018;6:448-457 ©2018 by American Association for Cancer Research