Host gene expression changes following exposure to the microbiota.

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Host gene expression changes following exposure to the microbiota. Host gene expression changes following exposure to the microbiota. (A) Heat map depicting averages across replicates of the log2(fold change) for each sample compared to the respective control (Low-4 and High-4 were compared to CO4, while Low-6 was compared to CO6). Green indicates a decrease in expression in the treatment sample, while purple indicates an increase in expression. One transcript from each of 6,684 genes that were DE in any of the 3 treatment groups (Benjamini-Hochberg adjusted P value of <0.1; |log2(fold change)| > 0.25) is shown. (B) Venn diagram depicting the number of genes that contained any transcript differentially expressed under the various treatment conditions. The overlap numbers require that the same gene was DE in the different samples. (C) Depiction of the percentage of DE genes from Camp et al. (either in CR or CV mice) that were DE in colonocytes in our study. P values are from a Fisher exact test on a two-by-two contingency table, looking at the overlap of DE genes in our data compared to DE genes in either CR or CV mice. Allison L. Richards et al. mSystems 2016; doi:10.1128/mSystems.00067-16