Increased growth factor receptor expression in lungs and tumors of hypoxic mice. Increased growth factor receptor expression in lungs and tumors of hypoxic.

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Increased growth factor receptor expression in lungs and tumors of hypoxic mice. Increased growth factor receptor expression in lungs and tumors of hypoxic mice. Lysates from lungs obtained from urethane-treated mice exposed to normoxia or hypoxia and tumors from normoxic and hypoxic mice were analyzed for growth factor receptor expression by Western blotting. β-Actin was used as a loading control. A, levels of EGFR, PDGFR, and FGFR2. B, a graphical representation of levels for various treatments. C, VEGFR1, VEGFR2, Tie1, and Tie2. D, the graphical representation of the levels for various treatments. Data shown are mean ± SEM and * indicates P ≤ 0.05 for comparisons between normoxia and hypoxia (n = 3 for each treatment). Vijaya Karoor et al. Cancer Prev Res 2012;5:1061-1071 ©2012 by American Association for Cancer Research