Hcy decreases VEGFR1/2 and Angs (Ang1, Ang2) gene transcription

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Hcy decreases VEGFR1/2 and Angs (Ang1, Ang2) gene transcription Hcy decreases VEGFR1/2 and Angs (Ang1, Ang2) gene transcription (A,B) RT-PCR analysis of VEGFR1 and VEGFR2 demonstrated that the treatment with different concentrations of Hcy reduces VEGFR1/2 mRNA in HUVECs. Data are expressed as fold increase compared with control cells treated with PBS only and are the mean ± S.E.M. of three experiments. Hcy significantly decreased Ang1 (C) and Ang2 (D) gene expression in a dose-dependent way. The data are representative of three independent experiments performed in triplicate. Statistical significance is expressed as **, P<0.001; *, P<0.05 compared with untreated control. Lemen Pan et al. Biosci. Rep. 2017;37:BSR20170860 ©2017 by Portland Press Ltd