Volume 19, Issue 4, Pages 551-552 (April 2014) Small Molecules Convert Fibroblasts into Islet-like Cells Avoiding Pluripotent State  Nadya Lumelsky  Cell Metabolism  Volume 19, Issue 4, Pages 551-552 (April 2014) DOI: 10.1016/j.cmet.2014.03.019 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Small Molecules Reprogram Mouse Embryonic Fibroblasts into Pancreatic Islet-like Cells Bypassing Pluripotent State Following induction of pluripotency genes, the unique combinations of small molecules guide direct reprogramming of embryonic fibroblasts into definitive endoderm-like cells, pancreatic progenitor-like cells, and pancreatic-like cells. This protocol is faster, more efficient, and potentially safer than earlier-developed protocols involving full reprogramming of fibroblasts into iPSCs followed by their differentiation into pancreatic-like cells. Cell Metabolism 2014 19, 551-552DOI: (10.1016/j.cmet.2014.03.019) Copyright © 2014 Elsevier Inc. Terms and Conditions