Pseudomonas PIV enhances pneumococcal pneumonia and bacteremia in C57BL/6 mice. Pseudomonas PIV enhances pneumococcal pneumonia and bacteremia in C57BL/6.

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Pseudomonas PIV enhances pneumococcal pneumonia and bacteremia in C57BL/6 mice. Pseudomonas PIV enhances pneumococcal pneumonia and bacteremia in C57BL/6 mice. Mice were intratracheally inoculated with 10 µg of Pseudomonas PIV, 106 CFU of pneumococci, or mixtures of 106 CFU pneumococci with 10 µg of respective Pseudomonas proteases. Pneumococcal burdens in the lungs (A) and blood (B) of mice were determined 2 days after lung infection. PIVIN, heat-inactivated PIV. PIV significantly increased pneumococcal burden in the murine lungs (A) and led to bacteremia (B). Data shown are representative of two independent experiments (n ≥ 6). Error bars represent standard errors of the means. *, P < 0.05; **, P < 0.01; ns, no significant difference. Jessica L. Bradshaw et al. mSphere 2018; doi:10.1128/mSphere.00212-18