Robust Replication of Genotype-Phenotype Associations across Multiple Diseases in an Electronic Medical Record Marylyn D. Ritchie, Joshua C. Denny, Dana.

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Robust Replication of Genotype-Phenotype Associations across Multiple Diseases in an Electronic Medical Record Marylyn D. Ritchie, Joshua C. Denny, Dana C. Crawford, Andrea H. Ramirez, Justin B. Weiner, Jill M. Pulley, Melissa A. Basford, Kristin Brown-Gentry, Jeffrey R. Balser, Daniel R. Masys, Jonathan L. Haines, Dan M. Roden The American Journal of Human Genetics Volume 86, Issue 4, Pages 560-572 (April 2010) DOI: 10.1016/j.ajhg.2010.03.003 Copyright © 2010 The American Society of Human Genetics Terms and Conditions

Figure 1 Identifying Cases and Controls The numbers presented are for European American subjects, with a definite diagnosis. Table S2 presents the numbers for other groupings studied here. The American Journal of Human Genetics 2010 86, 560-572DOI: (10.1016/j.ajhg.2010.03.003) Copyright © 2010 The American Society of Human Genetics Terms and Conditions

Figure 2 Odds Ratios for Comparisons of Cases versus Controls for Each SNP Evaluated These are ordered by the number of cases required for replication (“number needed” column), calculated from the previously reported odds ratio (ORPR, red square; see text). The blue diamonds indicate the point estimate of the allelic OR derived from the present analysis. The error bars indicate the confidence interval of the allelic OR derived from the present analysis. This analysis used only definite cases in which European ancestry had been assigned. AF, atrial fibrillation; CD, Crohn disease; MS, multiple sclerosis; RA, rheumatoid arthritis; T2D, type 2 diabetes. The American Journal of Human Genetics 2010 86, 560-572DOI: (10.1016/j.ajhg.2010.03.003) Copyright © 2010 The American Society of Human Genetics Terms and Conditions