ABT-888 sensitizes multiple ovarian cancer cell lines but not normal cells to FdUrd. ABT-888 sensitizes multiple ovarian cancer cell lines but not normal.

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ABT-888 sensitizes multiple ovarian cancer cell lines but not normal cells to FdUrd. ABT-888 sensitizes multiple ovarian cancer cell lines but not normal cells to FdUrd. A, A2780, SKOV3ip, OVCAR-5, and OVCAR-3 ovarian cancer cells were treated with FdUrd for 24 hours in combination with vehicle or the indicated concentrations of ABT-888 for 24 hours. Following washing, ABT-888 was readded to samples initially exposed to ABT-888, and cells were cultured until colonies formed. Data shown are a representative experiment from 3 independent replicates. n = 3 ± SD. B, OSEtsT/hTERT immortalized ovarian surface epithelial cells and WS1 human fibroblasts were treated with FdUrd with and without 3 μmol/L ABT-888. Cell viability was assessed via MTS assay. Data shown are the averages of 3 independent experiments. n = 3 ± SEM. Amelia M. Huehls et al. Cancer Res 2011;71:4944-4954 ©2011 by American Association for Cancer Research