Cancer-associated pathways and biomarkers of venous thrombosis

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Cancer-associated pathways and biomarkers of venous thrombosis by Yohei Hisada, and Nigel Mackman Blood Volume 130(13):1499-1506 September 28, 2017 ©2017 by American Society of Hematology

Neutrophilia increases thrombosis in lung cancer. Neutrophilia increases thrombosis in lung cancer. Tumor-derived G-CSF leads to increased levels of neutrophils, and these neutrophils release NETs that increase thrombosis in patients with lung cancer. EC, endothelial cell. Yohei Hisada, and Nigel Mackman Blood 2017;130:1499-1506 ©2017 by American Society of Hematology

Thrombocytosis increases thrombosis in ovarian cancer. Thrombocytosis increases thrombosis in ovarian cancer. Tumor-derived IL-6 stimulates hepatocytes to express thrombopoietin (TPO), which increases platelet production and enhances thrombosis in patients with ovarian cancer. Yohei Hisada, and Nigel Mackman Blood 2017;130:1499-1506 ©2017 by American Society of Hematology

Tumor-derived TF+ MVs trigger thrombosis in pancreatic cancer. Tumor-derived TF+MVs trigger thrombosis in pancreatic cancer. Pancreatic tumor cells release TF+ MVs into the circulation that trigger thrombosis in patients with pancreatic cancer. Yohei Hisada, and Nigel Mackman Blood 2017;130:1499-1506 ©2017 by American Society of Hematology

Tumor-derived, PDPN+ MVs trigger thrombosis in brain cancer. Tumor-derived, PDPN+MVs trigger thrombosis in brain cancer. Brain tumor cells may release PDPN+ MVs that activate circulating platelets and increase thrombosis in patients with brain cancer. Yohei Hisada, and Nigel Mackman Blood 2017;130:1499-1506 ©2017 by American Society of Hematology