Strategies for personalized precision immunotherapy. Strategies for personalized precision immunotherapy. After biopsy of the patient's tumor, whole-exome sequencing permits characterization of the tumor genome and identification of predicted neoantigens. This patient-specific information can then be utilized to individualize immunotherapy care against tumor-specific vulnerabilities. Rajarsi Mandal, and Timothy A. Chan Cancer Discov 2016;6:703-713 ©2016 by American Association for Cancer Research