Knights in Action: Lectin Receptor-Like Kinases in Plant Development and Stress Responses  Neha Vaid, Anca Macovei, Narendra Tuteja  Molecular Plant  Volume 6, Issue 5, Pages 1405-1418 (September 2013) DOI: 10.1093/mp/sst033 Copyright © 2013 The Authors. All rights reserved. Terms and Conditions

Figure 1 Line Model of the Three LecRLK Classes. In general, the LecRLKs are composed of an extracellular domain, a transmembrane region (TM), and a cytoplasmic Serine/Threonine kinase domain (STK). On the basis of its extracellular domain, the LecRLKs are classified into three classes: L-type, G-type, and C-type. (A) L-type LecRLK with legume lectin-like extracellular domain. (B) G-type LecRLK with α-mannose binding bulb lectin domain. This class of proteins also possesses a PAN and/or an EGF domain. (C) C-type LecRLKs characterized by the presence of calcium-dependent carbohydrate-binding domains. Molecular Plant 2013 6, 1405-1418DOI: (10.1093/mp/sst033) Copyright © 2013 The Authors. All rights reserved. Terms and Conditions

Figure 2 ClustalW Analyses of Representative L-Type LecRLK Proteins. The figure highlights all the domains and the important motifs in the LecRLK proteins. Molecular Plant 2013 6, 1405-1418DOI: (10.1093/mp/sst033) Copyright © 2013 The Authors. All rights reserved. Terms and Conditions

Figure 3 Hypothetical Model of LecRLKs’ Action Mode. Upon perceiving extracellular signals, the LecRLKs oligomerize and undergo auto- and transphosphorylation events leading to a cascade of intermediate proteins phosphorylation. The intermediate protein can either continue the cascade by downstream proteins phosphorylation, transcription factors activation, or hormonal pathways modulation, ultimately leading to activation of stress-responsive or developmental signal-responsive genes. The potential role of LecRLK as cell wall–plasma membrane linker is also shown. The model is based on the knowledge about the RLKs with the input of information available on LecRLKs. Since the family has not been extensively studied, the unknown pathways are depicted with dotted lines. Molecular Plant 2013 6, 1405-1418DOI: (10.1093/mp/sst033) Copyright © 2013 The Authors. All rights reserved. Terms and Conditions