WLBU2 disrupts P. aeruginosa biofilms during RSV coinfection of bronchial epithelial cells. WLBU2 disrupts P. aeruginosa biofilms during RSV coinfection.

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WLBU2 disrupts P. aeruginosa biofilms during RSV coinfection of bronchial epithelial cells. WLBU2 disrupts P. aeruginosa biofilms during RSV coinfection of bronchial epithelial cells. (A) P. aeruginosa cells recovered from biofilms grown on bronchial epithelial cells, either uninfected or infected with RSV, after 1.5 h of treatment with 500 ng/ml ciprofloxacin or 1 mg/ml tobramycin. (B) P. aeruginosa cells recovered from biofilms grown on RSV-infected bronchial epithelial cells after 1 h of treatment with 50 µM WLBU2 or LL-37 and viral replication in the epithelial cells. Bronchial epithelial cell nuclei are in blue, P. aeruginosa cells are in green, and RSV is in red. Scale bars, 100 µm. (C) Representative images and biomass quantification of P. aeruginosa biofilms during growth on RSV-infected bronchial epithelial cells before and after 1 h of treatment with 10 µM WLBU2. Data are means from three or more independent experiments. Error bars indicate standard deviations. *, P < 0.05; **, P < 0.01; ****, P < 0.0001. Jeffrey A. Melvin et al. mSphere 2016; doi:10.1128/mSphere.00083-16