The role of RAI2 in breast cancer metastasis.

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The role of RAI2 in breast cancer metastasis. The role of RAI2 in breast cancer metastasis. Differentiated breast cancer cells exhibit high levels of RAI2, which binds to the transcriptional corepressor C-terminal binding protein-2 (CTBP2) through a conserved ALDLS sequence, preventing it from suppressing the expression of breast cancer differentiation transcription factor genes GATA3, FOXOA1, and GRHL2. Metastatic cells lose expression of RAI2, allowing the suppression of differentiation transcription factors by CTBP2, and the development of EMT features that facilitate tumor dissemination. Mark Esposito, and Yibin Kang Cancer Discovery 2015;5:466-468 ©2015 by American Association for Cancer Research