Expression of chemokine receptors in A-498 cell line. Expression of chemokine receptors in A-498 cell line. Different chemokine receptors are expressed on RCC cell line A-498: A, mRNA levels of chemokine receptors are shown as the ratio of chemokine receptor mRNA to18S RNA. B, surface protein expression is shown as relative fluorescence intensities (filled histogram) compared with isotype controls (open histogram). Karin Jöhrer et al. Clin Cancer Res 2005;11:2459-2465 ©2005 by American Association for Cancer Research