Identification of putative TET1 targets in TNBC

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K. Brennan, J.L. Koenig, A.J. Gentles, J.B. Sunwoo, O. Gevaert

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Identification of putative TET1 targets in TNBC Identification of putative TET1 targets in TNBC. A, Frequency distribution of Spearman correlation r values (TET1 expression vs. Identification of putative TET1 targets in TNBC. A, Frequency distribution of Spearman correlation r values (TET1 expression vs. DNA methylation) in patients with TNBC. x-axis, correlation coefficient; y-axis, percent of correlated probes. Green, 1,000 permutations of the data; orange, real dataset. B, Location of putative TET1 targets and non-TET1 targets relative to CGIs. C, Unsupervised cluster analysis of methylation in TNBC for the putative TET1 targets (N = 17,521 sites), including 41 normal breast controls. D, Pathway analysis of putative TET1 targets. x-axis, –log10(P). E, Differential gene expression analysis between clusters 1 and 2. y-axis, –log10(P); x-axis, log2(cluster 1/cluster 2). Genes were considered upregulated if FC > 2 or FC < 0.5 and P < 0.05 (t test). F, Pathway analysis of genes that are hypomethylated and upregulated in cluster 1. Charly Ryan Good et al. Cancer Res 2018;78:4126-4137 ©2018 by American Association for Cancer Research