IL-33 is not critical for initiation of allergic airways disease phenotype. IL-33 is not critical for initiation of allergic airways disease phenotype.

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IL-33 is not critical for initiation of allergic airways disease phenotype. IL-33 is not critical for initiation of allergic airways disease phenotype. Three-day-old WT BALB/c and Il33−/−mice were exposed to intermittent doses of HDM or PBS. (A) Airway responsiveness to methacholine in neonatal WT and Il33−/− mice. (B) Pulmonary eosinophils (SiglecF+CD11clow/neg). Numbers of pulmonary (C) LinnegCD45+IL-13+ILCs and (D) CD3+CD4+IL-13+ T cells. Levels of (E) IL-33, (F) IL-5, and (G) IL-13 in the lung. n = 7 to 12 HDM, n = 6 to 8 PBS. Data are representative of two experiments. *P < 0.05, **P < 0.01, ***P < 0.001. Sejal Saglani et al. Sci. Immunol. 2018;3:eaan4128 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works