Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105. Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105.

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Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105. Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105. A, chemical structure of IG-105. B, cell cycle analysis for Bel-7402 cells untreated (0 h) or treated with IG-105 at 0.35 μmol/L for 3, 6, 9, 12, 18, and 24 h. The majority of the cells were arrested at G2-M phase after 9 h treatment. C, change of cyclins expression by IG-105. Bel-7402 cells were untreated (0 h) or treated with IG-105 (0.35 μmol/L) for 3, 6, 9, 12, 18, 24, and 36 h followed by protein extraction. Immunoblotting showed that cyclin B1 protein expression increased and cyclin D1 decreased after the treatment with IG-105. Yue-Ming Wang et al. Clin Cancer Res 2008;14:6218-6227 ©2008 by American Association for Cancer Research