The late G2 checkpoint controlling cell-cycle progression from G2 to M phase. The late G2 checkpoint controlling cell-cycle progression from G2 to M phase.

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The late G2 checkpoint controlling cell-cycle progression from G2 to M phase. The late G2 checkpoint controlling cell-cycle progression from G2 to M phase. Active Cdk1(cdc2) complexed to cyclin B1 is required for progression from G2 to M phase as shown. Regulation of the cdc2-B1 complex involves inhibitory phosphates at a pair of amino acids in the roof of the active site by Wee1. Dephosphorylation of these sites by the phosphatase Cdc25C increases Cdk activity. DNA damage activates Chk1, which inactivates Cdc25C through phosphorylation of cdc25C, resulting in the phosphorylation and inactivity of cdc2-B1 and G2-M arrest. Robert S. DiPaola Clin Cancer Res 2002;8:3311-3314 ©2002 by American Association for Cancer Research

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