CPGL is a growth suppressor in pancreatic cancer cell lines.

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Presentation transcript:

CPGL is a growth suppressor in pancreatic cancer cell lines. CPGL is a growth suppressor in pancreatic cancer cell lines. A, mRNA expression of the CPGL (black columns) and CPGL-B (gray columns) isoforms in pancreatic cancer cell lines carrying various copy numbers (CN) of the CPGL gene. B, Western blot analysis of CPGL and CPGL-B protein by anti-FLAG antibody in the indicated cell lines. NS, nonspecific band. C, proliferation curve of the SU-vector, SU-CPGL, and SU-CPGL-B cells. *, P value is 0.028 between the SU vector and SU-CPGL and is 0.019 between the SU vector and SU-CPGL-B. D, cell-cycle analysis. P < 0.05 in the comparison of G0/G1 phase of SU vector cells versus SU-CPGL or SU-CPGL-B cells, as well as in the comparison of S-phase of SU vector cells versus SU-CPGL or SU-CPGL-B cells. E, wound healing assay. Images were captured 8 hours after creation of wounds. Experiments were done in triplicate; vertical bars indicate SDs. Jih-Hsiang Lee et al. Clin Cancer Res 2012;18:524-533 ©2012 by American Association for Cancer Research