Rafal S. Sobota, Catherine M. Stein, Nuri Kodaman, Laura B

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A Locus at 5q33.3 Confers Resistance to Tuberculosis in Highly Susceptible Individuals Rafal S. Sobota, Catherine M. Stein, Nuri Kodaman, Laura B. Scheinfeldt, Isaac Maro, Wendy Wieland-Alter, Robert P. Igo, Albert Magohe, LaShaunda L. Malone, Keith Chervenak, Noemi B. Hall, Chawangwa Modongo, Nicola Zetola, Mecky Matee, Moses Joloba, Alain Froment, Thomas B. Nyambo, Jason H. Moore, William K. Scott, Timothy Lahey, W. Henry Boom, C. Fordham von Reyn, Sarah A. Tishkoff, Giorgio Sirugo, Scott M. Williams The American Journal of Human Genetics Volume 98, Issue 3, Pages 514-524 (March 2016) DOI: 10.1016/j.ajhg.2016.01.015 Copyright © 2016 The American Society of Human Genetics Terms and Conditions

Figure 1 Results for Imputed SNPs in a 50 kb Region around rs4921437 from an Additive Genetic Model for Association with TB in the Combined Cohort The imputed SNP with the most significant association, rs10515780, is in a purple. Colors represent LD (measured with r2) between available variants and rs10515780. Annotation of chromatin-state segmentation in the zoomed region around rs4921437 is from the UCSC Genome Browser (hg19) for nine human cell types (chr5: 158,680,000–158,700,000). Bright red indicates an active promoter, light red indicates a weak promoter, yellow represents a weak or poised enhancer, light green represents a weak transcribed state, and dark green indicates transcriptional transition or elongation. An H3K27Ac histone mark aligns with the most significant SNPs. The American Journal of Human Genetics 2016 98, 514-524DOI: (10.1016/j.ajhg.2016.01.015) Copyright © 2016 The American Society of Human Genetics Terms and Conditions