IL-1β expression is increased in MM cell lines by the co-culture with platelets in vitro. IL-1β expression is increased in MM cell lines by the co-culture.

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IL-1β expression is increased in MM cell lines by the co-culture with platelets in vitro. IL-1β expression is increased in MM cell lines by the co-culture with platelets in vitro. A, A gene expression heat map which shows up- or downregulated genes in OPM-2 cells co-cultured with platelets. OPM-2 cells were treated with Tyrode's buffer (Control, n = 3) or platelet (Platelet, n = 3). B, Increased interleukin–related gene enrichment and inflammatory response related gene enrichment from RNA-seq datasets comparing differential RNA expression between Control and Platelet. C, IL-1β protein level in the supernatant of co-cultured OPM-2 cells and the releasate of activated platelets were detected by the ELISA. Cells were co-cultured with platelets for 2 days. Platelet activation was induced by the TRAP treatment; **, P < 0.01. Satoshi Takagi et al. Clin Cancer Res 2018;24:2430-2439 ©2018 by American Association for Cancer Research