Acarbose reversibly changes the structure of the murine gut community.

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Acarbose reversibly changes the structure of the murine gut community. Acarbose reversibly changes the structure of the murine gut community. (A) Experimental setup detailing the four diet groups for the 4-week experiment, color-coded by diet type: PP, plant polysaccharide-rich chow; HS, high starch; control, no acarbose; low, low-dose acarbose; high, high-dose acarbose. The triangles represent when fecal samples were collected and analyzed for 16S rRNA. N = 5 mice per group. Note that samples taken on the diet transition day were collected just prior to diet change. (B) NMDS ordination based on Bray-Curtis dissimilarity applied to OTU abundances from fecal samples at time points indicated in A (low versus control diet, ANOSIM R = −0.02, P = 0.73; high versus control diet, ANOSIM R = 0.75, P = 0.001). Separate ordinations for each treatment group are compiled in Fig. S1 in the supplemental material. (C) Fecal SCFA concentrations from mice in the HS control and high-dose acarbose groups on day 21. *, P < 0.05 by Wilcoxon rank sum test. Nielson T. Baxter et al. mSphere 2019; doi:10.1128/mSphere.00528-18